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KMID : 0854720120320020067
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 2 p.67 ~ p.72
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Leukotrienes and Allergic Inflammation
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Kim Sang-Hoon
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Abstract
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Leukotrienes (LTs) are important lipid mediators involved in allergic inflammation. The LT pathway is relatively steroid- resistant, which suggests the possibility that its blockade by alternative means may facilitate asthma management. Cysteinyl LT receptor 1 antagonists are well accepted for their efficacy and safety in asthma management. Recent studies have revealed evolving findings indicating that leukotriene B4 has an important role in the development of asthma as well as in the potential importance of cysteinyl LTs in airway remodeling. These new findings provide important clues to achieve superior control of allergic inflammation.
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KEYWORD
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Cysteinyl-Leukotriene, Leukotriene B4, Asthma, Leukotriene antagonists
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